Based on these findings, it may be concluded that APLP2 expression in primary pancreatic cancer and corresponding metastasis could be a factor in pancreatic cancer aggressiveness, though APLP2 expression analysis in a large cohort will be required to correlate its clinical significance with tumor stage, response to conventional chemotherapy and radiation therapy, and patient survival. The gene discussed is APLP2; the disease is familial pancreatic carcinoma.