FGFR2 and gastric cancer: Several FGFR tyrosine kinase inhibitors (TKIs) such as dovitinib [6], ponatinib [10], NVP-BGJ398 [11] and AZD4547 [8] have been able to inhibit growth of GC cell lines harboring FGFR2 amplification and shrink tumor xenograft using the same FGFR2 amplified cell lines implanted in nude mice.