Initial implementation of this multiplexed SCODA mutation enrichment and detection assay focused on 46 mutations in 4 genes (BRAF, EGFR, KRAS, and PIK3CA), constituting a set of commonly encountered mutations of clinical relevance in colorectal and non-small cell lung cancers (Table 1) [15, 23-31]. The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.