The effect of PIP3 on MMP2 and migration/invasion of lung cancer cells was almost completely diminished after combination treatment with pBio-PHBT258I and siMIG7 (Figure 5B and Supplementary Figure 5), indicating that phospho-PHBT258 and MIG-7 are each responsible for part rather than all of the effects on cancer MMP2 activity and migration/invasion. Here, BCAR3 is linked to lung carcinoma.