Although both phospho-PHBT258 and MIG-7 increase E-cadherin suppressors such as Snail, ZEB-1 or Twist to enhance EMT [8, 9], downregulation of either phospho-PHBT258 or MIG-7 causes only partial (30-60%) rather than complete attenuation in lung cancer EMT [8, 9]. The gene discussed is TWIST1; the disease is lung carcinoma.