Inoculation of mice with these cells, however, demonstrated that on day 49 post-inoculation CL1-5EV-GL- and CL1-5shCont-GL-bearing mice developed more tumor nodules than mice bearing PHBT258 or MIG-7-downregulated CL1-5 such as CL1-5bPHBT258I-GL, CL1-5shMIG7-1-GL or CL1-5shMIG7-2-GL, whereas mice bearing CL1-5 with downregulation of both PHBT258 and MIG-7 (CL1-5bPHBT258I/shMIG7-1-GL, or CL1-5bPHBT258I/shMIG7-2-GL) did not develop any detectable tumors (Figure 6A and 6B). The gene discussed is CXCL9; the disease is neoplasm.