We recently reported that COX-2/PGE2 induces Akt/GSK-3β and wnt signaling (β-catenin/T-cell factor/lymphoid enhancer factor) to increase MIG-7 that inhibits protein phosphatase 2A (PP2A) to positively feedback on Akt/GSK-3β signaling and sustain cancer cell migration/invasion [8]. This evidence concerns the gene GSK3B and cancer.