SKP2 and neoplasm: All of these changes might play important role presenting crucial future biomarkers considering the fact that eight of the altered genes, including ACLY, CDC20, MCM2, MKI67, SKP2, SLC2A1, SNAI2, and STMN1, are believed to facilitate the tumor growth and metastasis [11-16], while BCL2L11, KRT14, and FOXC2 are responsible for tumor cells survival and dispense.