SKP2 and neoplasm: Separate analysis including 25 patients with the tumor located at different parts of the larynx indicated significant increase in10 analyzed genes in the tumor tissues when compared to the corresponding healthy tissues from the same patients (Figure S1) The genes that showed increased expression levels included BCL2L11, (p = 0.0121) (known as important regulator of apoptosis) as well as cell cycle regulatory genes such as CDC20, MCM2 MKI67 SKP2 and STMN1 (p = 0.0011, p = 0.0024, p = 0.0010, p = 0.0003, and p = 0.0057, respectively).