Individuals with certain MTHFR variants have significantly reduced enzyme function which can lead to excess homocysteine in the blood, a known independent risk factor for cardiovascular disease: 1) with only genetic data available, an individual could just be told whether or not they have increased risk for abnormal folate metabolism and a likely increased homocysteine level; or 2) with only laboratory data available, we could tell the individual if their homocysteine was elevated but we could not tell them why or how to address it. This evidence concerns the gene MTHFR and cardiovascular disorder.