In contrast, ANXA6, which encodes a calcium-dependent membrane and phospholipid binding protein, shows significant upregulation of expression in atopic skin compared to control skin (fold change 1.3, FDR p = 0.016) and lesional to nonlesional AD skin (fold change 2.4, p = 0.027), whereas expression is decreased in psoriatic versus healthy skin (fold change 0.7, p = 6.38 × 10−13) (Table S7). Here, ANXA6 is linked to Alzheimer disease.