The most highly significant variant at 5q33.1 (rs17728338) shows opposing effects on AD and psoriasis (MNM p = 3.96 × 10−38; Table S5) and lies 2 kb upstream of ANXA6 (MIM 114070) and 8 kb downstream of TNIP1 (MIM 607714). This evidence concerns the gene ANXA6 and Alzheimer disease.