HMOX1 and cancer: It should be noted that Keap 1 is an important target for the bioactivity of XN, such as cancer chemo-prevention, hepatic protection, anti-inflammation, because alkylation on Keap1 activates antioxidant enzymes, such as quinine reductase, NQO1, HO-1, via the regulations of Nrf2 [46,96,126].