HMOX1 and colorectal carcinoma: In the present candidate gene study, we extended our previous study of HMOX1 A-413T polymorphism in relation to diet, lifestyle and colorectal carcinogenesis in a study group of 383 CRC cases and 763 members of the comparison group to a larger cohort encompassing 928 number of cases and 1726 members of the comparison group and included more dietary factors.