GPRASP2 and autism spectrum disorder: Three genes were identified for Subject HI0765 with an XCI status of 77%:23% with moderate skewness including GPRASP2 located on the X chromosome which encodes a protein that may regulate a variety of G-protein coupled receptors associated with autism spectrum disorders and schizophrenia [48], as an X-linked gene approaching high skewness becomes an important candidate for causation of ASD in this female.