Neuropilin-1 (NRP-1/BDCA4/CD304) is a transmembrane C-type lectin found on plasmacytoid dendritic cells (pDCs).10 It was initially identified as a receptor for class III semaphorins (SEMA3s) mediating neuronal guidance and axonal growth.11 It was subsequently found to bind to VEGF that is a critical pro-angiogenic factor that induces proliferation and migration of endothelial cells to tumor vasculature.12 This evidence concerns the gene NRP1 and neoplasm.