There were no statistically significant differences between Neuropilin-1 positive and Neuropilin-1 negative patients regarding age, sex, lymphadenopathy, hepatosplenomegaly, CNS involvement, hemoglobin levels or platelets count, while there were statistically significant differences between Neuropilin-1 positive and Neuropilin-1 negative expression regarding leukocytes count, percentage of BM blast cells and serum LDH levels with higher leucocytes count, percentage of BM blasts and serum LDH in Neuropilin-1 positive patients (Table 2). The gene discussed is NRP1; the disease is Lymphadenopathy.