NRP1 and acute lymphoblastic leukemia: Furthermore, Neuropilin-1 expression is increased in representative human leukemia and lymphoma cell lines and in a panel of bone marrow specimens obtained from patients with acute lymphoblastic leukemia or acute myeloid leukemia compared with normal bone marrow.17 Neuropilin-1 also has been reported to be overexpressed in leukemic lymphocytes in patients with chronic lymphocytic leukemia (CLL).18 Therefore, NRP-1 could potentially be used as a target for ligand-directed therapy in leukemia and lymphoma.17