NFKB1 and pulmonary arterial hypertension: According to the results of the present study, it can be speculated that the high blood flow shear stress acted on the pulmonary artery endothelial cells, activating NF-κB signaling pathways and initiating gene transcription to produce vasoactive mediators, pulmonary vasoconstriction and pulmonary vascular remodeling, and thus leading to pulmonary hypertension.