The mRNA expression of VEGFR-3 in the metastasis-positive (72 cases) and metastasis-negative lymph nodes (26 cases) from the lymph node metastasis-positive group exhibited no statistically significant difference (0.158±0.158 vs. 0.123±0.115; t=0.993; P>0.05 Table II). This evidence concerns the gene FLT4 and metastatic malignant neoplasm in the lymph nodes.