FLT4 and metastatic malignant neoplasm in the lymph nodes: The mRNA expression levels of VEGFR-3 in the lymph nodes (98 samples) from the lymph node metastasis-negative group and metastasis-positive lymph nodes (72 samples) from the lymph node metastasis-positive group exhibited statistically significant differences (0.281±0.166 vs. 0.158±0.158; t=4.849, P<0.001; Table I).