In the present study, the following possible target genes were identified at 8p23.1 in a homozygous deleted region that was previously not considered to play a pathogenic role in SCC: MSRA, MFHAS1, CLDN23, DEFB106A, DEFB105A, LOC441316, FAM90A7P and LOC441318. Although involvement of these genes in the pathogenesis of SCC has not been previously mentioned, genetic mutations of these genes have consistently been reported in multiple tumor types (31–34). This evidence concerns the gene CLDN23 and neoplasm.