DHTKD1 and neoplasm: In a previous study, a tumor-specific apoptosis-inducing gene (apoptin) and a cancer-specific promoter (hTERTp) were inserted into the RAPAd adenoviral vector to obtain a novel, dual-specific antitumor oncolytic adenovirus, Ad-Apoptin-hTERT-E1a, as well as the control recombinant adenoviruses, Ad-Apoptin, Ad-EGFP and Ad-EGFP-hTERT-E1a (13).