NFKB1 and psoriasis: However, the expression level of IκBα was decreased and those of p-IκBα and p-p65 increased markedly in the psoriatic lesions, disclosing that activation of the NF-κB pathway was involved in the pathogenesis of psoriasis and that the hyperfunction of the NF-κB signal was induced, at least partially, by the decreased phosphorylation of IκB but not the increased levels of p65.