Turning to yet another line of evidence, the letter by Possemato et al. [21] continues to note that, across a set of 8 breast cancer cell lines, 4 with copy number amplifications of PHGDH had 8–12-fold higher PHGDH protein expression relative to nontransformed cell lines (lacking gene-based amplification). The gene discussed is PHGDH; the disease is breast carcinoma.