Echoing the need for human data first espoused by Snell [16] and Cho et al. [22], Locasale et al. [8] returned to their PHGDH amplification results and noted that since amplification in a single tumor type was most commonly found in melanoma, it may be of use to consider PHGDH expression and copy number gain in human melanoma tissue samples. This evidence concerns the gene PHGDH and melanoma.