For example, pointing to the work of Possemato et al. [21] which found that high PHGDH mRNA was associated with poor prognosis in breast cancer, Locasale et al. [8] undertook a bioinformatics analysis of multiple tumor microarray datasets in breast cancer and found strong associations (P < 0.0001) with several clinical parameters. The gene discussed is PHGDH; the disease is breast cancer.