Citing work by Achouri et al. [28] that reported successful cloning of the first mammalian PHGDH gene from a rat hepatoma in 1997, Cho et al. [22] used 300 cDNA clones randomly sequenced from a λ ZAP human Jurkat T-cell cDNA library to look for similarity to the known rat PHGDH gene. The gene discussed is PHGDH; the disease is hepatocellular carcinoma.