These studies have implicated CXCR3 signaling in processes as diverse as the recruitment of macrophages to allografts (Kakuta et al., 2012), the macrophage-mediated remodeling of blood vessels (Zhou et al., 2010) and the polarization of macrophages towards an M2 phenotype that promotes tumor progression (Oghumu et al., 2014). The gene discussed is CXCR3; the disease is neoplasm.