Thus, these data suggest that the disorders of the (COX-1) and (COX-2) cyclooxygenase path apply to the entire mucosa of patients with the aspirin triad, instead of being associated only with nasal polyps and the mucosa of the upper respiratory tract in patients diagnosed with the aspirin triad, and they cannot be associated with the healthy mucosa of patients without the triad [17]. The gene discussed is PTGS2; the disease is Nasal polyposis.