In the present study we build on this work by quantifying PIAS3 expression in squamous lung cancer tumors and cell lines by western blotting, determine its clinical correlation with survival using The Cancer Genome Atlas (TCGA) cohort of squamous lung cancer patients, and demonstrate upregulation of endogenous PIAS3 expression by curcumin, providing proof-in-principal that PIAS3 can be a potential target in lung cancer therapy. Here, PIAS3 is linked to lung cancer.