We hypothesized that polyamines could decrease LPS-induced cognitive impairment by interfering in cytokine levels because: (1) LPS, at doses that cause cognitive impairment, sequentially increases brain IL-6, IL-1β, and TNF-α mRNA levels in the hippocampus [77,78] and frontal cortex [79]; (2) LPS-induced upregulation of IL-1β and TNF-α mRNA in hippocampal tissue of IL-6(+/+) mice is absent in IL-6(−/−) mice, which are also refractory to the LPS-induced impairment in working memory [77]. This evidence concerns the gene IL1B and Cognitive impairment.