In addition, thalidomide, which is one of the standard treatment options for multiple myeloma, can suppress VEGF production and tumour proliferation.17 Previous case reports or case series reported that thalidomide improved or stabilised the clinical symptoms in patients with POEMS syndrome and decreased serum VEGF levels,8, 18, 19 and that it could be safely administered to patients who were not eligible for HDCT with ASCT because of older age or poor condition. This evidence concerns the gene VEGFA and neoplasm.