In addition, loss of the 18q21 chromosome region, harboring the Smad4 gene, is commonly observed in ~60% of pancreatic and 30% of colorectal cancers (106–109) has been shown to promote angiogenesis and tumor growth by inducing vascular endothelial growth factor (VEGF) expression (60,110). The gene discussed is VEGFA; the disease is colorectal cancer.