TGFB1 and neoplasm: As a result, the increase in matrix protein synthesis and decrease in matrix proteinase activity, owing to the TGFβ activity, contributes to the remodeling of the tumor ECM and can result in a fibrotic response, known as desmoplasia, which is commonly observed in many types of tumors and particularly in pancreatic, colon and breast cancers as well as in various sarcomas (155,156).