Particularly, targeting with TGFβ agents (e.g., 1D11, AP12009, SD-208) as well as non-specific targeting with other TGFβ inhibitory drugs (e.g., tranilast) have shown to reduce tumor progression and metastasis in vivo, mainly owing to augmentation of the immune response and inhibition of EMT (132,168–171). This evidence concerns the gene TGFB1 and neoplasm.