CD8A and chronic obstructive pulmonary disease: There was a significant increase in CD28null CD8+ NKT-like cells in patients with COPD compared with healthy controls but no change in CD28null CD8- NKT-like cells (CD28nullCD8 + NKT-like: 38 ± 6.4 (23 ± 4.3); CD28nullCD8-T: 8.3 ± 3.1 (7.4 ± 2.8) for COPD patients (controls)).