Our study offers the novel finding that expression of GSN, PHF17, and ZFP30 is involved in conferring cellular sensitivity to PD-0325901: GSN is involved in the assembly and disassembly of actin filaments needed for cellular replication [29]; PHF17 is a known tumor suppressor and promotes apoptosis [30]; and ZFP30 is thought to be involved in regulating transcription. This evidence concerns the gene JADE1 and neoplasm.