Several genes (for example, RIPK2, EFNA4 and TMEM9B) (Figure 9B, Additional file 12: Figure S9 and Additional file 13: Figure S10) showed differential expression in subtypes associated with high proliferation, such as IntClust 5 (predominantly HER2/ERBB2-amplified cancers) and IntClust 10 (predominantly basal expression type cancers). The gene discussed is RIPK2; the disease is cancer.