The effects of EPO were studied from a physiological, pathological and molecular perspective, and indicators of cardiac function, the inflammatory response, serum creatine kinase (CK), myocardial histopathology and cardiomyocyte apoptosis were detected to determine whether EPO exerted a protective effect on the heart and other major organs (liver, kidney and lung) in sepsis. The gene discussed is EPO; the disease is Sepsis.