Following treatment with EPO, the pathological damage to the heart was significantly reduced, and the degree of damage to the other major organs (liver, kidney and lungs) was also significantly reduced, suggesting that in the early treatment of sepsis, attention should be paid to the protection and support of the functions of the heart and other organs in order to prevent the occurrence of multiple organ failure and to reduce the sepsis-associated mortality rate. This evidence concerns the gene EPO and Multiple Organ Failure.