MAPK1 and ovarian carcinoma: We noted a significant overlap (P-value = 9.5 × 10−4; hypergeometric test, Figure 3b) between predicted drivers and validated ESP genes, including several that are rarely mutated in ovarian cancer (e.g. MAPK1 (1.6%) and JUN (2.2%)) and with functions consistent with cancer driver genes (Supplementary Tables S5).