Furthermore, statistical analysis confirmed that breast tumors with a high expression of human epidermal growth factor receptor 2 (HER2) showed a higher expression level of HMGA1 (P=0.007) and a higher expression level of HMGA1 was also found in the ductal breast cases compared with the lobular breast cancer cases (P=0.000) (Table II and Fig. 5A). This evidence concerns the gene ERBB2 and breast neoplasm.