This hypothesis is sustained by the evidences that S100B is absent from human fetal salivary glands tissue from 32 weeks of gestation onwards and in adulthood [38] and, therefore the increase in S100B is an event that usually occurs in the blood, cerebrospinal fluid and urine of full-term asphyxiated newborns with HIE [10, 14, 16, 17]. Here, S100B is linked to perinatal asphyxia.