Coronary heart disease and congestive heart failure have been previously associated with impaired cognitive function.30–32 However, by the time cognitive impairment becomes clinically apparent significant cerebral damage may have already occurred in the brain.33,34 Hence, early markers of cardiac dysfunction such as NT-proBNP and hs-cTnT are of interest so that timely interventions may be employed. The gene discussed is NPPB; the disease is Cognitive impairment.