In overall comparison, there was obvious evidence of an association between XRCC6 rs2267437 polymorphism and increased cancer risk (GG vs. CC: OR = 1.33; 95% confidence intervals (CI), 1.09–1.62; recessive model (GG vs. CC/CG): OR = 1.21; 95% CI 1.00–1.47) (Table 6  and Figure 1B). Here, XRCC6 is linked to cancer.