ESR2 and Familial prostate cancer: However, BPA also interacts with AR, inducing nuclear translocation of the tumor-derived receptor (AR-T877A) and subsequent binding to the response elements.116 As AR-negative prostate cancer cells fail to show growth inhibition after exposure to high doses of BPA,117 both ER-β and AR could mediate the actions of BPA in advanced prostate adenocarcinomas, but only the role of AR may be essential.