INS and Insulin resistance: Using insulin resistance as a predictor of age-related hypertension, coronary heart disease, stroke, cancer, and type 2 diabetes, the study [48] demonstrated that approximately 1 out of 3 healthy individuals in the upper tertile of insulin resistance had developed an age-related clinical event, followed for an average of 6 years, whereas no clinical events were observed in the most insulin-sensitive tertile [48].