ITIH4 and infection: HIV-1goes into the brain at the early stages of infection and leads to damage and impairment of the central nervous system Mannose binding lectin binds to the N-linked mannose residues on gp120, a neurotoxin, and is instrumental in intravesicular packaging of gp120 in neuronal subcellular organelles and subcellular trafficking of gp120 through the endoplasmic reticulum and Golgi vesicles.The vesicular complexes were translocated along the microtubule network A functional carbohydrate recognition domain necessary for the actions of mannose binding lectin [92].