IL17A and osteoporosis: In an animal model of vulvovaginal candidiasis, inhibition of Th17 differentiation led to significant inhibition of IL-17 production [101] and in mice model of estrogen-deficient osteoporosis halofuginone reduces the abundance of Th-17 cells and prevents estrogen-deficient osteoporosis by diminishing bone resorption without impacting osteogenesis [102].