There are some reports describing the use of different lectins for evaluation of cell surfaces [172,173], for blood typing [174,175], as mitogenic agents [176,177,178,179,180], to detect changes in cellular transformation [181,182], in the clearance of sulfated glycoprotein hormones, control of glycoprotein biosynthesis, cell-cell interactions in the immune system [183] and associated with susceptibility and severity in a wide variety of infectious and autoimmune diseases [184,185]. Here, ART4 is linked to autoimmune disease.