IFNG and infection: Our results suggest that in this experimental model, IFN-γ gene expression may mediate immunopathology and that the high IFN-γ levels in later stages of infection may be an attempt to control the elevated parasitic load in the skin lesion.Although post-transcriptional or post-translational modifications may additionally regulat the target genes of interest, different publications have described a good correlation between cytokine gene expression quantified by RT-qPCR and cytokine secretion as measured by ELISA [39].