Despite the scoring of hnRNPA1 and hnRNPA2 fall below the cut-off for prion identification in yeast sequences using pWALTZ and also in composition based algorithms like PAPA, it has been recently reported that discrete missense mutations in the PFD of hnRNPA1 (D262V and D262N) and hnRNPA2 (D290V) cause multisystem proteinopathy and amyotrophic lateral sclerosis [34]. The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.