ANGPT2 and Plasmodium falciparum malaria: In falciparum malaria, clinical severity and mortality are also independently associated with impaired microvascular function [13] and with increased angiopoietin-2 (Ang-2) [32], a key product of endothelial Weibel-Palade Bodies (WPB) and an autocrine mediator of endothelial activation [33].