LYN has predicted edges with four polymorphic genes in this subnetwork: BLK, BANK1, CSK, and GRB10. LYN also has connections to the polymorphic, bridge genes PLAUR and LCP2 (see below), and suppressors of cytokine signaling genes SOCS2 and SOCS3. The conserved finding of high expression of LYN in the inflammatory subset and its centrality within the adaptive immune subnetwork suggests that LYN plays a key role in the adaptive immune component of SSc in skin. This evidence concerns the gene CSK and systemic sclerosis.