Comparison of the expression of Smad3 and Rif1 between teratoma cells and teratocarcinoma cell lines F9 and P19 revealed that Smad3 was significantly lower in teratocarcinoma cells than teratoma cells, whereas Rif1 is significantly higher in teratocarcinoma cells than teratoma cells (Supplementary Figures S7A and S7B). The gene discussed is SMAD3; the disease is teratoma.