Tam was shown to induce ROS and oxidative stress in breast cancer cells, hepatoblastoma cells, retinal cells and platelets through activation of NAD(P)H oxidase, the enzyme that also promotes ROS production in macrophages.32, 42, 43, 44, 45, 46 The ROS-boosting effect of Tam was extended and further validated by our study in adipocytes and adipose tissues. The gene discussed is FMO5; the disease is hepatoblastoma.