The AKT signaling pathway controls cell proliferation, growth, and survival, and is frequently deregulated in cancers as a result of gene mutation, amplification, or loss or mutation of its negative regulator PTEN.26 As BTG3 has been implicated in tumor suppression,14, 27 we wondered whether it would be involved in the regulation of AKT. The gene discussed is AKT1; the disease is neoplasm.