A growing number of reports suggests the existence of a widespread interaction network involving ceRNAs, where ncRNAs could regulate modulatory RNA by binding and titrating them off their binding sites on protein coding messengers.13, 28 An example of this type of regulation is exemplified by HULC, an lncRNA highly upregulated in liver cancer, whose upregulated expression is in part to its inhibitory effects on the expression and activity of miRNA-372 (Wang et al.29). This evidence concerns the gene HULC and liver cancer.