We found that ADAMTS18 expression was completely silenced in all of the ccRCC-derived cell lines but was present in 2 normal renal cell lines (HEK293 and HK-2), as shown in Figure 1A. These results indicate that ADAMTS18 is frequently downregulated in ccRCC-derived cell lines. The gene discussed is ADAMTS18; the disease is nonpapillary renal cell carcinoma.