CFH and age-related macular degeneration: Two of the major loci that were reported in several family-based linkage studies, 1q31 and 10q26 were the subject of candidate gene testing of variants in both family-based and case-control cohorts and led to the discovery of the roles of complement factor H (CFH) [2,3,4,5] and the ARMS2/HTRA1 genes [6,7] in AMD risk.