Insulin resistance could be attributed to a decrease in insulin responsiveness, a decrease in insulin sensitivity or both.17 Studies in nonpregnant and nonlactating dairy cow have demonstrated that the elevation of circulating NEFAs following a fasting period27,28 or by intravenous administration of a tallow infusion 29 resulted in insulin resistance and an impaired insulin-stimulated glucose uptake by insulin-sensitive tissues. The gene discussed is INS; the disease is Insulin resistance.