Increase of β2M in urine at early stage of cadmium exposure has been demonstrated.24 Tsuchiya et al. showed that β2M in urine is very closely correlated with againg.25 Hyperthyroidism is another stimulant of β2M production.26 In our study significant increase in β2M, Cr and BUN in diabetic rabbits were observed. The gene discussed is B2M; the disease is hyperthyroidism.