Others have already shown that these proteins are related to resistance to HDACi as single agents.[9] The Bcl-2 family members regulates the intrinsic cell death pathway by controlling permeability of the outer mitochondrial membrane.[10] In addition, by binding the endoplasmic reticulum, these proteins regulate autophagy by binding to Beclin-1.[11] Inhibiting these Bcl-2 family proteins may provide an effective strategy in overcoming resistance to HDACi.[12] A recent study has shown efficacy of the Bcl-2 inhibitor ABT-737 and SAHA in an immortalized glioma model. Here, BCL2 is linked to central nervous system cancer.