BCL2 and mantle cell lymphoma: [32] In mantle cell lymphoma, the efficacy of SAHA was enhanced by the BH-3 mimetic ABT-263.[33] In contrast, another study did not find HDACi efficacy to be related to Bcl-2 family proteins.[31] Thus, these relationships between Bcl-2 family proteins and HDACi responses are either tumor type or HDACi specific.